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1

Impact of physiological, physicochemical and biopharmaceutical factors in absorption and metabolism mechanisms on the drug oral bioavailability of rats and humans

Hurst, Susan, Loi, Cho-Ming, Brodfuehrer, Joanne, El-Kattan, Ayman

Journal:

Expert Opinion on Drug Metabolism & Toxicology

Year:

2007

Language:

english

File:

PDF, 493 KB

english, 2007

2

The effect of terpene enhancer lipophilicity on the percutaneous permeation of hydrocortisone formulated in HPMC gel systems

Ayman F El-Kattan, Charles S Asbill, Bozena B Michniak

Journal:

International Journal of Pharmaceutics

Year:

2000

Language:

english

File:

PDF, 175 KB

english, 2000

3

Encyclopedia of Reagents for Organic Synthesis || Sodium Methoxide

El-Kattan, Yahya

Year:

2001

Language:

english

File:

PDF, 252 KB

english, 2001

4

Reconciling Human-Canine Differences in Oral Bioavailability: Looking beyond the Biopharmaceutics Classification System

Martinez, Marilyn N., El-Kattan, Ayman, Awji, Elias, Papich, Mark

Journal:

The AAPS Journal

Year:

2019

Language:

english

File:

PDF, 2.08 MB

english, 2019

5

The effects of terpene enhancers on the percutaneous permeation of drugs with different lipophilicities

Ayman F. El-Kattan, Charles S. Asbill, Nanhye Kim, Bozena B. Michniak

Journal:

International Journal of Pharmaceutics

Year:

2001

Language:

english

File:

PDF, 151 KB

english, 2001

6

The road map to oral bioavailability: an industrial perspective

Thomas, V Hayden, Bhattachar, Shobha, Hitchingham, Linda, Zocharski, Philip, Naath, Maryanne, Surendran, Narayanan, Stoner, Chad L, El-Kattan, Ayman

Journal:

Expert Opinion on Drug Metabolism & Toxicology

Year:

2006

Language:

english

File:

PDF, 263 KB

english, 2006

7

pH-Dependent Solubility and Permeability Criteria for Provisional Biopharmaceutics Classification (BCS and BDDCS) in Early Drug Discovery

Varma, Manthena V., Gardner, Iain, Steyn, Stefanus J., Nkansah, Paul, Rotter, Charles J., Whitney-Pickett, Carrie, Zhang, Hui, Di, Li, Cram, Michael, Fenner, Katherine S., El-Kattan, Ayman F.

Journal:

Molecular Pharmaceutics

Year:

2012

Language:

english

File:

PDF, 1.97 MB

english, 2012

8

Involvement of drug transporters in organ toxicity: the fundamental basis to drug discovery and development

Cheng, Yaofeng, El-Kattan, Ayman F, Zhang, Yan, Ray, Adrian S., Lai, Yurong

Journal:

Chemical Research in Toxicology

Year:

2016

Language:

english

File:

PDF, 1.50 MB

english, 2016

9

In utero MRI diagnosis of fetal malformations in oligohydramnios pregnancies

Said, Ahmed Hesham, El-Kattan, Eman, Abdel-Hakeem, Ahmed K., Saleem, Sahar

Journal:

The Egyptian Journal of Radiology and Nuclear Medicine

Year:

2016

Language:

english

File:

PDF, 1.10 MB

english, 2016

10

Navigating Transporter Sciences in Pharmacokinetics Characterization Using Extended Clearance Classification System (ECCS)

El-Kattan, Ayman F, Varma, Manthena V S

Journal:

Drug Metabolism and Disposition

Year:

2018

Language:

english

File:

PDF, 1.96 MB

english, 2018

11

Synergistic effects of curing conditions and magnesium oxide addition on the physico-mechanical properties and firing resistivity of Portland cement mortar

Abdel-Gawwad, H.A., Abo El-Enein, S.A., Heikal, Mohamed, Abd El-Aleem, S., Amer, A.A., El-Kattan, I.M.

Journal:

Construction and Building Materials

Year:

2018

Language:

english

File:

PDF, 6.80 MB

english, 2018

12

Effect of exogenous progesterone treatment on ovarian steroid hormones and oxidant and antioxidant biomarkers during peak and low breeding seasons in dromedary she-camel

El-Maaty, Amal M. Abo, Mohamed, Ragab H., Hozyen, Heba F., El-Kattan, Adel M., Mahmoud, Mona A., Ali, Amal H.

Journal:

Veterinary World

Year:

2019

Language:

english

File:

PDF, 663 KB

english, 2019

13

Oral treatment with PD-0200347, an α2δ ligand, reduces the development of experimental osteoarthritis by inhibiting metalloproteinases and inducible nitric oxide synthase gene expression and synthesis in cartilage chondrocytes

Christelle Boileau, Johanne Martel-Pelletier, Julie Brunet, Ginette Tardif, Denis Schrier, Craig Flory, Ayman El-Kattan, Martin Boily, Jean-Pierre Pelletier

Journal:

Arthritis & Rheumatism

Year:

2005

Language:

english

File:

PDF, 503 KB

english, 2005

14

ChemInform Abstract: A General Synthetic Method of 5-Carboranyluracil Nucleosides with Potential Antiviral Activity and Use in Neutron Capture Therapy.

N. M. GOUDGAON, Y. A. EL-KATTAN, X. XIA, J. MCATEE, J. SORIA, S.-J. WEY, D. C. LIOTTA, R. F. SCHINAZI

Journal:

Year:

1998

File:

PDF, 25 KB

1998

15

ChemInform Abstract: Tin(IV) Chloride Mediated Glycosylation in Arabinofuranose, Galactofuranose and Rhamnopyranose.

A. K. PATHAK, Y. A. EL-KATTAN, N. BANSAL, J. A. MADDRY, R. C. REYNOLDS

Journal:

Year:

1998

File:

PDF, 33 KB

1998

16

Comparison of the anti-influenza virus activity of cyclopentane derivatives with oseltamivir and zanamivir in vivo

Pooran Chand, Shanta Bantia, Pravin L. Kotian, Yahya El-Kattan, Tsu-Hsing Lin, Yarlagadda S. Babu

Journal:

Bioorganic & Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 161 KB

english, 2005

17

Corrigendum to “Design, parallel synthesis, and crystal structures of biphenyl antithrombotics as selective inhibitors of tissue factor FVIIa complex. Part 1: Exploration of S2 pocket pharmacophores” [Bioorg. Med. Chem. 17 (2009) 3934]

Pravin L. Kotian, Raman Krishnan, Scott Rowland, Yahya El-Kattan, Surendra K. Saini, Ramanda Upshaw, Shanta Bantia, Shane Arnold, Y. Sudhakar Babu, Pooran Chand

Journal:

Bioorganic & Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 94 KB

english, 2010

18

Oxadiazolone bioisosteres of pregabalin and gabapentin

David J. Wustrow, Thomas R. Belliotti, Thomas Capiris, Clare O. Kneen, Justin S. Bryans, Mark J. Field, Dic Williams, Ayman El-Kattan, Lisa Buchholz, Jack J. Kinsora, Susan M. Lotarski, Mark G. Vartan

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 164 KB

english, 2009

19

Fetal MRI in the evaluation of fetuses referred for sonographically suspected neural tube defects (NTDs): impact on diagnosis and management decision

Sahar N. Saleem, Ahmed-Hesham Said, Maged Abdel-Raouf, Eman A. El-Kattan, Maha Saad Zaki, Noha Madkour, Mostafa Shokry

Journal:

Year:

2009

Language:

english

File:

PDF, 355 KB

english, 2009

20

How Modeling and Simulation Have Enhanced Decision Making in New Drug Development

Raymond Miller, Wayne Ewy, Brian W. Corrigan, Daniele Ouellet, David Hermann, Kenneth G. Kowalski, Peter Lockwood, Jeffrey R. Koup, Sean Donevan, Ayman El-Kattan, Cheryl SW Li, John L. Werth, Douglas

Journal:

Journal of Pharmacokinetics and Pharmacodynamics

Year:

2005

Language:

english

File:

PDF, 174 KB

english, 2005

21

Design, parallel synthesis, and crystal structures of biphenyl antithrombotics as selective inhibitors of tissue factor FVIIa complex. Part 1: Exploration of S2 pocket pharmacophores

Pravin L. Kotian, Raman Krishnan, Scott Rowland, Yahya El-Kattan, Surendra K. Saini, Ramanda Upshaw, Shanta Bantia, Shane Arnold, Y. Sudhakar Babu, Pooran Chand

Journal:

Bioorganic & Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 1.30 MB

english, 2009

22

Tin(IV) chloride mediated glycosylation in arabinofuranose, galactofuranose and rhamnopyranose

Ashish K. Pathak, Yahya A. El-Kattan, Namita Bansal, Joseph A. Maddry, Robert C. Reynolds

Journal:

Tetrahedron Letters

Year:

1998

Language:

english

File:

PDF, 198 KB

english, 1998

23

ChemInform Abstract: Nitrogen Glycosylation Reactions Involving Pyrimidine and Purine Nucleoside Bases with Furanoside Sugars

L. J. WILSON, M. W. HAGER, Y. A. EL-KATTAN, D. C. LIOTTA

Journal:

Year:

1996

File:

PDF, 25 KB

1996

24

OP05.02: 3D multislice analysis of ultrasound volumes for the prenatal diagnosis of central nervous system fetal malformations

M. Momtaz, A. Ebrashy, M. Aboulghar, I. El-Kattan, M. Sherif, A. Hamed

Journal:

Ultrasound in Obstetrics & Gynecology

Year:

2009

Language:

english

File:

PDF, 50 KB

english, 2009

25

Evaluation of derivatives of 3-(2-oxo-1-pyrrolidine) hexahydro-1H-azepine-2-one as dermal penetration enhancers: side chain length variation and molecular modeling

N Kim, A.F El-Kattan, C.S Asbill, R.J Kennette, J.W Sowell Sr., R Latour, B.B Michniak

Journal:

Journal of Controlled Release

Year:

2001

Language:

english

File:

PDF, 499 KB

english, 2001

26

Transdermal testing: practical aspects and methods

El-Kattan, Ayman, Asbill, Charles S, Haidar, Sam

Journal:

Pharmaceutical Science & Technology Today

Year:

2000

Language:

english

File:

PDF, 174 KB

english, 2000

27

Full efficacy with no CNS side-effects: unachievable panacea or reality? DMPK considerations in design of drugs with limited brain penetration

Cole, Susan, Bagal, Sharan, El-Kattan, Ayman, Fenner, Katherine, Hay, Tanya, Kempshall, Sarah, Lunn, Graham, Varma, Manthena, Stupple, Paul, Speed, William

Journal:

Year:

2012

Language:

english

File:

PDF, 1.11 MB

english, 2012

28

Uterine–umbilical artery Doppler velocimetry and pregnancy outcome in SLE patients: Relation to disease manifestations and activity

Tamer A. Gheita, Sherif M. Gamal, Eman El-Kattan

Journal:

The Egyptian Rheumatologist

Year:

2011

Language:

english

File:

PDF, 684 KB

english, 2011

29

Modulation of NMDA receptor function by inhibition of d-amino acid oxidase in rodent brain

Christine A. Strick, Cheryl Li, Liam Scott, Brian Harvey, Mihály Hajós, Stefanus J. Steyn, Mary A. Piotrowski, Larry C. James, James T. Downs, Brian Rago, Stacey L. Becker, Ayman El-Kattan, Youfen Xu,

Journal:

Neuropharmacology

Year:

2011

Language:

english

File:

PDF, 1.30 MB

english, 2011

30

Comparative pharmacokinetics of marbofloxacin in healthy and Mannheimia haemolytica infected calves

M. Ismail, Y.A. El-Kattan

Journal:

Research in Veterinary Science

Year:

2007

Language:

english

File:

PDF, 156 KB

english, 2007

31

A Practical Large-Scale Synthesis of (3 R ,4 R )-4-(Hydroxymethyl)pyrrolidin-3-ol via Asymmetric 1,3-Dipolar Cycloaddition

Kotian, Pravin L., Lin, Tsu-Hsing, El-Kattan, Yahya, Chand, Pooran

Journal:

Organic Process Research & Development

Year:

2005

Language:

english

File:

PDF, 59 KB

english, 2005

32

Characterization of Organic Anion Transporting Polypeptide (OATP) Expression and Its Functional Contribution to the Uptake of Substrates in Human Hepatocytes

Kimoto, Emi, Yoshida, Kenta, Balogh, Larissa M., Bi, Yi-an, Maeda, Kazuya, El-Kattan, Ayman, Sugiyama, Yuichi, Lai, Yurong

Journal:

Molecular Pharmaceutics

Year:

2012

Language:

english

File:

PDF, 1.31 MB

english, 2012

33

Physicochemical Determinants of Human Renal Clearance

Varma, Manthena V. S., Feng, Bo, Obach, R. Scott, Troutman, Matthew D., Chupka, Jonathan, Miller, Howard R., El-Kattan, Ayman

Journal:

Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 1.03 MB

english, 2009

34

Physicochemical Space for Optimum Oral Bioavailability: Contribution of Human Intestinal Absorption and First-Pass Elimination

Varma, Manthena V. S., Obach, R. Scott, Rotter, Charles, Miller, Howard R., Chang, George, Steyn, Stefanus J., El-Kattan, Ayman, Troutman, Matthew D.

Journal:

Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 1.17 MB

english, 2010

35

Model-based approaches to predict drug–drug interactions associated with hepatic uptake transporters: preclinical, clinical and beyond

Barton, Hugh A, Lai, Yurong, Goosen, Theunis C, Jones, Hannah M, El-Kattan, Ayman F, Gosset, James R, Lin, Jian, Varma, Manthena V

Journal:

Expert Opinion on Drug Metabolism & Toxicology

Year:

2013

Language:

english

File:

PDF, 671 KB

english, 2013

36

Diethylation Labeling Combined with UPLC/MS/MS for Simultaneous Determination of a Panel of Monoamine Neurotransmitters in Rat Prefrontal Cortex Microdialysates

Ji, Chengjie, Li, Wenlin, Ren, Xiao-dan, El-Kattan, Ayman F., Kozak, Rouba, Fountain, Scott, Lepsy, Christopher

Journal:

Analytical Chemistry

Year:

2008

Language:

english

File:

PDF, 266 KB

english, 2008

37

Development and evaluation of novel solid nanodispersion system for oral delivery of poorly water-soluble drugs

Nkansah, Paul, Antipas, Amy, Lu, Ying, Varma, Manthena, Rotter, Charles, Rago, Brian, El-Kattan, Ayman, Taylor, Graeme, Rubio, Mario, Litchfield, John

Journal:

Journal of Controlled Release

Year:

2013

Language:

english

File:

PDF, 1.42 MB

english, 2013

38

Effect of chitosan glutamate, carbomer 974P, and EDTA on the in vitro Caco-2 permeability and oral pharmacokinetic profile of acyclovir in rats

Merzlikine, Alexei, Rotter, Charles, Rago, Brian, Poe, Julie, Christoffersen, Curt, Thomas, V. Hayden, Troutman, Matthew, El-Kattan, Ayman

Journal:

Drug Development and Industrial Pharmacy

Year:

2009

Language:

english

File:

PDF, 418 KB

english, 2009

39

Discovery, SAR, and Pharmacokinetics of a Novel 3-Hydroxyquinolin-2(1 H )-one Series of Potent d -Amino Acid Oxidase (DAAO) Inhibitors †

Duplantier, Allen J., Becker, Stacey L., Bohanon, Michael J., Borzilleri, Kris A., Chrunyk, Boris A., Downs, James T., Hu, Lain-Yen, El-Kattan, Ayman, James, Larry C., Liu, Shenping, Lu, Jiemin, Makla

Journal:

Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 767 KB

english, 2009

40

BCX-1812 (RWJ-270201): Discovery of a Novel, Highly Potent, Orally Active, and Selective Influenza Neuraminidase Inhibitor through Structure-Based Drug Design

Babu, Y. Sudhakar, Chand, Pooran, Bantia, Shanta, Kotian, Pravin, Dehghani, Ali, El-Kattan, Yahya, Lin, Tsu-Hsing, Hutchison, Tracy L., Elliott, Arthur J., Parker, Cynthia D., Ananth, Sandya L., Horn,

Journal:

Journal of Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 363 KB

english, 2000

41

Quantitative Prediction of Renal Transporter-Mediated Clinical Drug–Drug Interactions

Feng, Bo, Hurst, Susan, Lu, Yasong, Varma, Manthena V., Rotter, Charles J., El-Kattan, Ayman, Lockwood, Peter, Corrigan, Brian

Journal:

Molecular Pharmaceutics

Year:

2013

Language:

english

File:

PDF, 634 KB

english, 2013

42

Disposition kinetics of doxycycline in chickens naturally infected with Mycoplasma gallisepticum

Ismail, M.M., El-Kattan, Y.A.

Journal:

British Poultry Science

Year:

2004

Language:

english

File:

PDF, 116 KB

english, 2004

43

Encyclopedia of Reagents for Organic Synthesis || Nafion-H

El-Kattan, Yahya

Year:

2001

Language:

english

File:

PDF, 61 KB

english, 2001

44

Systematic Structure-Based Design and Stereoselective Synthesis of Novel Multisubstituted Cyclopentane Derivatives with Potent Antiinfluenza Activity

Chand, Pooran, Kotian, Pravin L., Dehghani, Ali, El-Kattan, Yahya, Lin, Tsu-Hsing, Hutchison, Tracy L., Babu, Y. Sudhakar, Bantia, Shanta, Elliott, Arthur J., Montgomery, John A.

Journal:

Journal of Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 273 KB

english, 2001

45

Synthesis of 9-[1-(Substituted)-3-(phosphonomethoxy)propyl]adenine Derivatives as Possible Antiviral Agents

Wu, Minwan, El-Kattan, Yahya, Lin, Tsu-Hsing, Ghosh, Ajit, Vadlakonda, Satish, Kotian, Pravin L., Babu, Yarlagadda S., Chand, Pooran

Journal:

Nucleosides Nucleotides & Nucleic Acids

Year:

2005

Language:

english

File:

PDF, 674 KB

english, 2005

46

Syntheses and Neuraminidase Inhibitory Activity of Multisubstituted Cyclopentane Amide Derivatives

Chand, Pooran, Babu, Y. Sudhakar, Bantia, Shanta, Rowland, Scott, Dehghani, Ali, Kotian, Pravin L., Hutchison, Tracy L., Ali, Shoukath, Brouillette, Wayne, El-Kattan, Yahya, Lin, Tsu-Hsing

Journal:

Journal of Medicinal Chemistry

Year:

2004

Language:

english

File:

PDF, 201 KB

english, 2004

47

pH-Sensitive Interaction of HMG-CoA Reductase Inhibitors (Statins) with Organic Anion Transporting Polypeptide 2B1

Varma, Manthena V., Rotter, Charles J., Chupka, Jonathan, Whalen, Kevin M., Duignan, David B., Feng, Bo, Litchfield, John, Goosen, Theunis C., El-Kattan, Ayman F.

Journal:

Molecular Pharmaceutics

Year:

2011

Language:

english

File:

PDF, 2.68 MB

english, 2011

48

Synthesis of 9-[1-(1-Hydroxyethyl)-3-(Phosphonomethoxy)Propyl] Adenine and Prodrug as Possible Antiviral Agents

Ghosh, Ajit, Chand, Pooran, El-Kattan, Yahya, Wu, Minwan, Lin, Tsu-Hsing, Vadlakonda, Satish, Kotian, Pravin L., Babu, Yarlagadda S.

Journal:

Nucleosides Nucleotides & Nucleic Acids

Year:

2005

Language:

english

File:

PDF, 282 KB

english, 2005

49

Comparative pharmacokinetics of florfenicol in the chicken, pigeon and quail

Ismail, M., El-Kattan, Y.A.

Journal:

British Poultry Science

Year:

2009

Language:

english

File:

PDF, 128 KB

english, 2009

50

New acyclic nucleoside analogues. Stereospecific synthesis of purines and pyrimidines substituted with chiral chains by sugar-ring opening of ?-D-galactopyranosyl nucleosides

El-Kattan, Yahya, Gosselin, Gilles, Imbach, Jean-Louis

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

1994

Language:

english

File:

PDF, 1.27 MB

english, 1994